Cloning and Characterization of Expanded CAG-Repeat Containing Sequence(s): Identification of Candidate Breast Cancer Gene(s)
Abstract
Genetic factors have been shown to influence the risk of developing breast cancer. To date only two breast cancer predisposition genes, BRCA1 and BRCA2, have been identified. A wide spectrum of BRCA mutations has been found in breast cancer families. However, in the majority of breast cancer cases BRCA1 or BRCA2 mutations were not detected, suggesting the presence of other breast cancer predisposition genes. Trinucleotide repeats are present widely in human genome. Expansions of some trinucleotide repeats have been recognized to be the cause of several genetic disorders. In a previous study we have utilized the Repeat Expanded Detection (RED) method to investigate the distribution of (CAG) repeats in a sample of 212 breast cancer and 196 normal population controls and in 20 breast cancer mother-daughter pairs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA418567
Entities
People
- Hilmi Ozcelik
Organizations
- Mount Sinai Hospital, Toronto