Beta III Tubulin, Disulfide Bonds and Drug Resistance: A Novel Approach to the Treatment of Breast Cancer

Abstract

Tubulin, a potential target for chemotherapy, plays an important role in different cellular functions including mitosis and cell division. Tubulin consists of mainly alpha and beta subunits: each subunit exists in several isoforms. The distribution and expression of beta- isoforms differ from tissue to tissue: beta(II) and beta(IV) are ubiquitously expressed while beta(III) expression is restricted to neurons and cancer cells. Moreover, alpha beta (III) has least affinity for anti-tubulin drugs. In this study, we correlated the expression and structural stability of beta(III)-tubulin in response to oxidative stress in cancer and drug resistant cells.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2003
Accession Number
ADA418572

Entities

People

  • Asish R. Chaudhuri

Organizations

  • University of Texas Health Science Center at San Antonio

Tags

DTIC Thesaurus Topics

  • Biochemistry
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Cysteine
  • Drug Resistance
  • Free Radicals
  • Health Services
  • Ionizing Radiation
  • Neoplasms
  • Oxidation
  • Oxidative Stress
  • Resistance

Fields of Study

  • Biology
  • Chemistry

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and Cellular Biochemistry