Ribozyme Targeting the Novel Fusion Junction of EGFRvIII in Breast Cancer

Abstract

EGFRvIII is a tumor specific, ligand-independent, constitutively activated variant of the epidermal growth factor receptor. We have detected high frequency of EGFRvIII expression in breast cancer. We also detected high frequency of co-expression of wt-EGFR with EGFRvIII mRNA in the same invasive breast carcinoma. Expression of EGFRvIII by ribozyme revealed down-regulation of EGFRvIII expression and reduced the tumorigenicity in athymic nude mice. These results suggest that EGFRvIII plays a significant role in breast cancer cell proliferation.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2003
Accession Number
ADA418630

Entities

People

  • Careen K. Tang

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cells
  • Diseases And Disorders
  • Frequency
  • Gene Expression
  • Genetics
  • Growth Factors
  • Medical Personnel
  • Mrna
  • Neoplasms
  • Polymerase Chain Reaction
  • Statistical Analysis
  • Therapy
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.