GADD45 Family of Genes in Breast Cancer
Abstract
The overall theme of the proposed research is to examine whether deficiency in the Growth Arrest & DNA Damage (Gadd)45 family of genes (Gadd45a & Gadd45b ), playing important roles in controlling cell division and response of cells to anti-cancer agents, contributes to breast carcinogenesis. To this end, a multifaceted research plan takes advantage of established models of breast cancer prone mice (Balb/c, MMTV-ras, MMTV-c-myc) that are being crossed with mouse strains deficient for Gadd45a or Gadd45a/b to generate breast cancer prone mouse strains deficient for Gadd45 genes. Such mouse strains will provide attractive animal models to assess how deficiency in Gadd45 genes promotes breast carcinogenesis under different experimental settings (i.e. with or without hormone stimulation, irradiation or the chemical carcinogen DMBA).
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA418639
Entities
People
- Dan Liebermann
Organizations
- Temple University