Herpes Virus Therapy of Prostate Cancer

Abstract

To improve the efficacy of intravenous administration of herpes vectors for metastatic prostate cancer we conducted experiments in the Tramp model system using clinically applicable agents that have been previously shown to transiently inactivate complement activity and demonstrate that dextran sulfate was effective in enhancing the tumor inhibitory activity of G207 efficiently infects human endothelial cells (HUVEC) at a low MOI 0.01 and kills >80% if cells by day 3.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2003
Accession Number
ADA418644

Entities

People

  • Robert L. Martuza

Organizations

  • Massachusetts General Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Blood Vessels
  • Cell Line
  • Cells
  • Chemotherapeutic Agents
  • Chemotherapy
  • Cyclophosphamide
  • Cytokines
  • Endothelial Cells
  • Health Services
  • Infection
  • Lymphocytes
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Therapy

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).
  • Virology (or Medical Virology).