A Novel Spatially and Temporally Inducible Gene Expression Vector for the Treatment of Metastatic Breast Cancer
Abstract
A major problem in current standard therapy for breast cancer is systemic toxicity. The overall objective of this proposal is to develop a novel strategy to confine and enhance therapeutic gene expression to tumors spatially and temporally with a novel expression vector. To achieve this, a new vector, pBF ( breast tumor specific, feed forward) was constructed to selectively enhance the level of cytotoxic agents at breast tumor sites relative to the rest of the body by using a feed-forward reaction based on a combination of tissue specific promoter (cerbB2p) and the tetracycline promoter (tetp) system.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA418682
Entities
People
- Anne T'ang
Organizations
- Children's Hospital Los Angeles