Treatment Strategies for the NMDA Component of Organophosphorus Convulsions
Abstract
The project is designed to evaluate anticonvulsant and neuroprotectant properties of novel medical countermeasures to lithium-pilocarpine (Li-pilo) induced status epilepticus (SE) used here as a model of organophosphorus nerve agents. The nonbarbiturate anesthetic propofol was found to induce significant anticonvulsant and neuroprotectant effects in Li-pilo SE. The strychnine-insensitive glycine site partial agonists 1-aminocyclopropanecarboxylic acid (ACPC) and D-cycloserine had no anticonvulsant activity but ACPC induced significant neuroprotection. Although ongoing, studies involving the spin-trap N-tert-alpha-(2 sulfophenyl)-nitrone (S-PBN) and the nonsteroidal anti-inflammatory drug mefenamic acid indicate neuroprotection without anticonvulsant activity for both agents. It is concluded that neuroprotection may be induced even in intractable seizures.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA418693
Entities
People
- James Griffith
- Steven L. Peterson
Organizations
- University of New Mexico