Genes Differentially Expressed at the Transition from Premalignancy to Carcinoma
Abstract
The objective of this project is to identify genetic differences existing between atypical ductal hyperplasia (ADH), which are premalignant cancer precursor lesions, and ductal carcinoma in situ (DCIS), the earliest recognized human breast malignancy. We hypothesize that investigation of these differences should identify genes whose dysregulation is important to the transition to malignancy. To achieve this objective, the project's first aim is to optimize techniques to preserve mammary glands, cut and stain sections, identify and microdissect areas of interest (i.e, hyperplasia and cancer), extract RNA and assess its quantity and quality.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA418732
Entities
People
- Carol L. Rosenberg
Organizations
- Boston Medical Center