Novel Drug Delivery Technique for Breast Cancer Therapy
Abstract
This report describes the progress achieved during the second year of the project. We proposed to complete Task 2 and begin to implement Task 3 in the second year of the project. Task 2 (a and b) focuses on in vivo studies of ultrasound-induced penetration of real anti-cancer drugs in human MCF-7 breast tumors of nude mice. Tasks 2a and 2b are devoted to in vivo studies of ultrasound-induced penetration of real anti cancer drugs: 5- FU and Interleukin-2, respectively, in the breast tumors. We conducted these studies to implement the proposed tasks. Our data obtained with the use of histological evaluation of the tumors indicate that the ultrasound produces enhanced delivery of the anti-cancer drugs in the tumors. This results in dramatic tumor necrosis that was obtained when mice were injected with the anti-cancer drug (5-PU or Interleukin-2) and the tumors were irradiated by ultrasound, while minor tumor necrosis was noticed when the drug was used without irradiation. At present, according to our research schedule, we are performing the studies proposed in the Task 3: to study efficacy of breast cancer therapy with the use of ultrasound-enhanced delivery of anti-cancer drug 5-PU.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA418735
Entities
People
- Rinat O. Esenaliev
Organizations
- University of Texas Medical Branch