Mechanisms for Controlling Breast Cancer Growth and Skeletal Metastasis
Abstract
The aim of this project was to understand the role and the mechanism of bone morphogenetic protein-2 (BMP-2, a protein mainly known to help in bone remodeling) in breast cancer cell growth and bone metastasis. To this end we have conclusively shown that BMP-2 is a potent inhibitor of breast cancer cell growth in a nude mouse xenograft model. We have also been successful in establishing an animal model to study bone metastasis from xenograft experiments. We have recently got data from our preliminary experiments to suggest that BMP-2 has the potential to reduce osteolysis following breast cancer development in the nude mice model. For the past year during the no cost extension period of my project we tried to develop some new ideas related to our findings from this project. We looked at the mechanism of BMP-2 induced inhibition of breast cancer cell growth in the tumors formed in the presence of BMP-2. We also started to look into the role of dietary supplements to increase the growth inhibitory property of BMP-2 in this mouse model. The proposed experiments were include in a new DOD IDEA proposal this year and is pending review later this year. The preliminary experiments point to an interesting finding showing that fish oil supplement in diet of mice can effectively reduce breast cancer cell growth and BMP-2 might be involved in this mechanism.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA418736
Entities
People
- Nandini Ghosh-choudhury
Organizations
- University of Texas Health Science Center at San Antonio