Metastasis Genes in Breast Cancer Metastasis to Bone

Abstract

The most prevalent site of breast cancer metastasis is bone. We will begin to elucidate the molecular mechanisms involved in bone metastasis. We propose to develop and utilize green (GFP) and/or red (dsRed) fluorescent protein-tagged breast carcinoma xenografts to measure bone metastasis following intracardiac injection. Cell lines developed will be used to test whether a metastasis suppressor (BRMSl) and a gene it down-regulates (osteopontin) alter the efficiency of bone colonization. Concomitantly, we will test the impact of changed gene expression on the ability of tumor cells to adhere to human osteoblast cell cultures or human bone marrow endothelium.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2003
Accession Number
ADA418755

Entities

People

  • Danny R. Welch

Organizations

  • Pennsylvania State University

Tags

DTIC Thesaurus Topics

  • Bone And Bones
  • Bone Diseases
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Genetics
  • Health Services
  • Medical Personnel
  • Oncology

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Oncology (Cancer Research).