Recombinational Repair Genes and Breast Cancer Risk
Abstract
It was hypothesized in my proposal that DNA double strand break (DSB) repair could be one of the most important factors in breast tumor suppression, considering functions of BRCA1 and BRCA2 in DSB repair by homologous recombination (1). In addition, elevated radiosensitivity of lymphocytes from unselected breast cancer patients has been reported (2), implicating that individual difference in DSB repair may contribute to breast cancer susceptibility. DSB repair in mammals is not well understood, so there might be some unidentified genes which may influence breast cancer risk. I have chosen forward genetics approaches such as phenotype-driven mutagenesis to identify such new genes and to investigate their biological roles in the context of a whole organism.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA418792
Entities
People
- Naoko Shima