Monitoring Cancer Oxygenation Changes Induced by Ultrasound

Abstract

This research is aimed at testing a new hypothesis that oxygen delivery to the localized tumor region can be enhanced by ultrasound at the diagnostic radiation level. A new portable frequency-domain multi-channel three-wavelength near infrared (NIR) diffusive imager has been built and calibrated for oxygenated hemoglobin and deoxygenated hemoglobin measurements. A 128-channel ultrasound system has been instrumented for insonification. A total of 3 Fisher rats were injected with the cancer cell line of 9L/Laz (gliosarcoma) and exposed to ultrasound. The ultrasound intensity has been controlled by adjusting the voltage and the pulse repetition - frequency. Dramatic changes were observed consistently in one rat, and further experiments are planned to verify the findings.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2003
Accession Number
ADA418861

Entities

People

  • Daqing Piao
  • Quing Zhu

Organizations

  • University of Connecticut

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cell Line
  • Cells
  • Detection
  • Detectors
  • Frequency
  • Health Services
  • Intensity
  • Laser Diodes
  • Measurement
  • Monitoring
  • Neoplasms
  • Optical Properties
  • Oxygenation
  • Radiation
  • Repetition Rate
  • Ultrasounds

Fields of Study

  • Physics

Readers

  • Cardiovascular Physiology
  • Image Processing and Computer Vision.