Studies on the Novel Anticancer Agents Metabolically Formed from 17-Beta-Estradiol

Abstract

By using NMR and mass spectrometric analyses, we determined the structures of Xl and X2, two representative nonpolar estrogen metabolites, which were metabolically formed following multiple large-scale incubations of 17 beta-estradiol with human CYP3A4 and NADPH. Both Xl and X2 were unequivocally identified to be the dimers of l7 beta-estradiol, connected together through a diaryl ether bond between a phenolic oxygen atom of one l7 beta-estradiol molecule and the 2- or 4-position aromatic carbon of another estrogen. This is the first report for a novel class of the nonpolar l7 beta-estradiol dimers that are formed from l7 beta- estradiol by human Cyp isoforms in the presence of NADPH as a cofactor.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2003
Accession Number
ADA418901

Entities

People

  • Anthony J. Lee

Organizations

  • University of South Carolina

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Antineoplastic Agents
  • Biomedical Research
  • Classification
  • Electronic Mail
  • Information Operations
  • Maryland
  • Monitoring
  • Security
  • South Carolina
  • Universities

Fields of Study

  • Chemistry

Readers

  • Molecular and genetic basis of cancer.
  • Munitions and Ordnance Engineering
  • Thin Film Deposition Science.