The Role of a FGF-Binding Protein in Breast Cancer
Abstract
Under this grant we studied the role and regulation of a secreted, fibroblast growth factor binding protein (FGF-BP) that can enhance angiogenesis and growth factor activity. We found that FGF-BP is highly expressed in approximately 112 of invasive breast cancers and rarely in normal breast or in in situ carcinoma. The FGF-BP gene is regulated in breast cancer cells by growth factors such as EGF. This regulation occurs at the transcriptional level and utilizes the transcription factor family C/EBPbeta as a major mechanism that involves interaction between activating and inhibitory isoforms of transcription factors. Expression of FGF-BP as a transgene is lethal during embryogenesis in mice or in chicken embryos. Studies on mammary carcinogenesis in mice thus required the establishment of regulatable transgene expression and a tetracycline-regulated system was generated for this.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2003
- Accession Number
- ADA418909
Entities
People
- Anton Wellstein
Organizations
- Georgetown University