The Role of a FGF-Binding Protein in Breast Cancer
Abstract
We studied the mechanisms of regulation of the FGF binding protein (FGF-BP) in breast cancer cells and evaluated its function in initial studies as a transgene in mice. We demonstrate that the FGF-BP gene is regulated at the transcriptional level in MDA-MB 468 cells. The promoter elements contributing are delineated. Initial studies with transgenic animals show that the FGF-BP gene expressed under a constitutively active promoter (CMV, K14, MMTV) causes embryonic lethality around mid-gestation time.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2001
- Accession Number
- ADA418913
Entities
People
- Anton Wellstein
Organizations
- Georgetown University