Functional Characterization of TPF (Tumor Promoting Factor), a Novel Angiogenic Factor in Breast Cancer Pathogenesis

Abstract

The primary goal of this project is to test the hypothesis that a newly identified protein, periostin, functions as an angiogenic factor to promote tumor progression and metastasis. As our previous results support this assumption, we in this final report have conducted additional experiments to generate substantial evidence for strengthening our conclusion. We wish to firmly establish an important functional role for periostin in the pathological process of breast carcinogenesis and lay the foundation for the development of novel therapeutics for the treatment of breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2003
Accession Number
ADA418988

Entities

People

  • Rong Shao
  • Xiao-Fan Wang

Organizations

  • Duke University Hospital

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Angiogenesis
  • Antibodies
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Culture Techniques
  • Endothelial Cells
  • Integrins
  • Neoplasms
  • North Carolina
  • Pathogenesis
  • Proteins
  • Regulations
  • Tumor Cell Line

Fields of Study

  • Medicine

Readers

  • Mechanical Engineering/Mechanics of Materials.
  • Oncology (Cancer Research).