Mathematical Models of the Use of Caffeine as a Countermeasure Deterioration of Neurobehavioral Functioning During Circadian Misalignment and Sleep Deprivation

Abstract

This project seeks a quantitative description of the dynamics of homeostatic and circadian influences on human sleep/wake patterns, cognitive and psychomotor performance. Equations have been developed by R. Kronauer and M. Jewett for the circadian/homeostatic interaction, as well as for the photic entrainment of the circadian pacemaker. See Journal of Biological Rhythms, December 1999, Vol. 14, Issue 6 for a complete statement of these models. Data from human forced desynchrony trials were used to test and evaluate the model, and to estimate parameters. Predictions were examined for measures of cognitive throughput as well as for measures of subjectively-assessed fatigue. Effects of caffeine were studied. Software incorporating the mathematical model and findings from several empirical studies was developed to simulate and predict human performance in a variety of sleep/wake routines.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2002
Accession Number
ADA418990

Entities

People

  • Megan E. Jewett

Organizations

  • Brigham and Women's Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biological Rhythms
  • Caffeine
  • Chronobiology
  • Circadian Rhythms
  • Countermeasures
  • Entrainment
  • Jet Lag
  • Mathematical Models
  • Models
  • Motor Skills
  • Pacemakers
  • Phase Modulation
  • Psychomotor Performance
  • Simulations
  • Sleep Deprivation
  • Throughput

Fields of Study

  • Psychology

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Computational Modeling and Simulation