Human Metabolism and Interactions of Deployment-Related Chemicals

Abstract

This study examines the human-metabolism and metabolic interactions of a subset of deployment-related chemicals, including chlorpyrifos, DEET, permethrin, pyridostigmine bromide, and sulfur mustard metabolites. Chiorpyrifos is metabolized by cytochiome P450 (CYP) isoforms with the ratio between activation and detoxication varying dramatically between different isoforms and polymorphisms. DEET is metabolized by several CYP isoforms while permethrin is first hydrolyzed then metabolized to phenozybenoic acid by alcohol and aldehyde dehydrogenases. Pyridostigmine bromide is not readily metabolized by human enzymes preparations. Chiorpyrifos and other organophosphorus compounds have considerable potential for interactions since they are potent inhibitors of DEET, carbaryl and testosterone metabolism by CYP.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2003
Accession Number
ADA419139

Entities

People

  • Ernest Hodgson

Organizations

  • North Carolina State University

Tags

DTIC Thesaurus Topics

  • Chemical Synthesis
  • Chemistry
  • Enzyme Inhibitors
  • Ethnic Groups
  • Genetics
  • Liquid Chromatography
  • Medical Personnel
  • Organic Chemistry
  • Organophosphates

Readers

  • Molecular and Cellular Biochemistry
  • Toxicology/Environmental Toxicology