Direct Effects of Folate Metabolism on Gene Expression in Metastatic Breast Cancer
Abstract
Ab proteins are small GTPases that are essential elements of the protein transport machinery of eukaryotic cells. Each round of membrane transport requires a cycle of Rab protein nucleotide binding and hydrolysis. Ny research project consists in the study of Rab GTPases, the way in which they regulate intracellular transport, and the elucidation of mechanisms by which proteins involved in intracellular protein trafficking are linked to uncontrolled cellular proliferation and cancer. Our laboratory has extensively characterized Yiplp, membrane proteins which appear to play a role in Rab-mediated membrane transport in Saccharomyes cerevisiae. The major accomplishment this final year was the elucidation of the importance of the prenylation on the activity and localization of Rab GTPases. The results will be discussed in terms of the relevance to treatment for human cancers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA419141
Entities
People
- Monica Calero
- Ruth N. Collins
Organizations
- Cornell University