Expression of Transforming Growth Factor-Beta (TGF-Beta) in Prostate Cancer Progression

Abstract

We have changed from using rats to mice. This change was approved by the DOD review committee. Our hypothesis is that if we render the host immune cells insensitive to TGF-beta, these immune cells would be able to eradicate tumor cells. There are three talks. Task 1 was to establish a dominant negative TGF-beta type II receptor bearing bone marrow cells, using GFP as a selectable marker. Task 2 was to test the role of TGF-beta insensitivity in immune cell development and differentiation. Task 3 was to assess the anti-tumor activity in host animals bearing TGF-beta insensitive bone marrow cells.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2003
Accession Number
ADA419151

Entities

People

  • Chung Lee

Organizations

  • Northwestern University

Tags

DTIC Thesaurus Topics

  • Blood
  • Bone Marrow
  • Bone Marrow Cells
  • Cancer
  • Carcinoma
  • Cardiovascular System
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Colon Cancer
  • Gene Therapy
  • Lymphatic System
  • Lymphocytes
  • Prostate Cancer
  • Stem Cells
  • Tissues

Fields of Study

  • Biology
  • Medicine

Readers

  • Oncology (Cancer Research).