Prostate Cancer in Nigerians, Jamaicans and U.S. Blacks
Abstract
The purpose of this research is to develop the infrastructure for comparative studies of prostate cancer among blacks who reside in contrasting environmental settings, West Africa, the Caribbean and the United States. This effort addresses six areas: case recruitment, case characterization, tissue collection and storage, integrated database development, targeted laboratory expertise and pilot research. Kev Research Accomplishments-Year 3: 1) Established a research infrastructure that supports unified measurement of exposure and prostate cancer disease in Chicago, Illinois and Kingston, Jamaica; 2) Completed molecular in over 40% of subjects enrolled; 3) Created a computerized database linking demographical, clinical and pathological characteristics of each case to archived tissue specimens and results of nutritional and genetic measurements; 4) Completed statistical comparisons of i) demographical, clinical and pathological characteristics of cases from Chicago, Kingston and West Africa; ii) levels of antioxidants and fatty acids in serum and prostate tissue in cases diagnosed in Chicago and Jamaica; iii) and have performed association studies between variants of genes involved in androgen metabolism and clinical stage of prostate cancer within and across cases from Chicago, Jamaica and West Africa; 6) Our first manuscript was accepted to the journal The Prostate and initial findings from our pilot studies have been presented at national meetings. The remainder of the no-cost extension will be used to complete and submit manuscripts and research grant proposals based on our work thus far.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2003
- Accession Number
- ADA419191
Entities
People
- Vincent L. Freeman
Organizations
- Loyola University New Orleans