Computational, Experimental and Engineering Foundations of Ionic Channels as Miniaturized Sensors, Devices and Systems

Abstract

Continuum and Particle methods were employed to simulate ion channels to study their characteristic properties like ion permeation and selectivity in order to demonstrate ion channels as biosensors. Fast, efficient and accurate simulators for modeling the conduction, selectivity and sensitivity of ionic channels have been developed. The continuum simulators were based on 3-D Poisson-Nernst-Planck (PNP) theories and stochastic dynamics. The transport coefficients and parameters (such as mobility, diffusivity, permittivity, etc.) were extracted from molecular dynamic simulations and from experimentation. The continuum theories are being tested by extensive experimentation to establish the range of validity of the PNP theories.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2003
Accession Number
ADA419204

Entities

People

  • Eric Jakobsson
  • Karl Hess
  • Narayan R. Aluru
  • Robert S. Eisenberg
  • Umberto Ravaioli

Organizations

  • University of Illinois Urbana–Champaign

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Carbon Nanotubes
  • Chemical Synthesis
  • Chemistry
  • Computational Science
  • Dielectric Permittivity
  • Electromagnetic Fields
  • Engineering
  • Fullerenes
  • Geometry
  • Mechanics
  • Membrane Potentials
  • Molecular Dynamics
  • Molecular Mechanics Methods
  • Physical Theories
  • Simulators
  • Three Dimensional

Readers

  • Computational Fluid Dynamics (CFD)
  • Nanocomposite Materials Science
  • Thermal Physics or Thermal Science.

Technology Areas

  • Biotechnology