Chemoprevention of Ovarian Cancer
Abstract
The overarching hypothesis of this program project is that 4-HPR (a synthetic vitamin A) and oral contraceptives (OCP) induce apoptosis, possibly through induction of TGFb production by stromal cells, as well as by direct interaction with the surface epithelial cells and these two cell types may act synergistically. In Project 1, 18 adult Rehesus monkeys were give 4-HPR1 OCP, the combination or no medication for 3 months. There were consistent differences in the absolute fluorescence intensities and relative contributions noted between pre- and post-drug measurements in each drug group. A second study involving 30 Cynomolgus macacues and using a crossover design has been completed; immunohistochemical analysis of several biomarkers and analysis of the fluorescence spectroscopy data are ongoing. Project 2 has been transferred to the University of Arizona with the relocation of Dr. Molly Brewer. Now that a supply of 4-HPR has been obtained from the NCI, this study should be ready for patient accrual within the next few weeks pending final approval of revisions by HSRRB. In Project 3, we have focused on understanding the mechanism of action of 4-HPR in tissue culture using both normal and immortalized epithelial cells. Studies are ongoing, and results to date are inconclusive.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2003
- Accession Number
- ADA419214
Entities
People
- David Gershenson
Organizations
- The University of Texas MD Anderson Cancer Center