Bone Mineral Density, Sex Steriod Genes, Race and Prostate Cancer Risk
Abstract
The goal of this project is to determine whether bone mineral density (assumed to be an integrated marker of sex steroid hormone exposure) is a risk factor for prostate cancer; and (2) to identify prostate cancer susceptibility alleles among genes in the sex steroid pathway. To address these aims, we are undertaking a case-control study of African American and Caucasian men in Pittsburgh, PA and Baltimore, MD. Cases are 100-150 African American and 150 Caucasian men with histologically-confirmed prostate cancer. Controls are age and race frequency-matched men who have a PSA <3.0 ng/mL. Hip, spine, and total body BMD is measured by Dual energy X-ray Absorptionmetry (DXA). Blood is used to obtain D%A. Polymerase Chain Reaction (PCR) techniques will be used to determine allelic distributions of genotypes for sex steroid metabolism, biosynthesis and action genes. Risk factor data are obtained by an in-person interview. Pathology information will be collected using standardized medical abstraction and all pathology will be confirmed by a central pathologist. Upon completion recruitment and data collection, we will evaluate the role of BMD and candidate genotypes in prostate cancer risk by race. We will further examine the interaction between BMD and genotypes to evaluate the hormonal environment - gene interaction and its effect on prostate cancer risk.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA419215
Entities
People
- Francesmary Modugno
Organizations
- University of Pittsburgh