Evaluation of Chronic Stress Induced Neurodegeneration and Treatment Using an In Vivo Retinal Model
Abstract
This project is developing the snake eye/Scanning Laser Ophthalmoscope model for use as a longitudinal damage model in the study of neural injury/neurodegenerative disease. This model is an in vivo, non-invasive imaging technique and provides the unique ability to observe cellular changes in the retina. Progress has been made in three areas of research necessary to establish the snake eye as a model for human neural injury/disease: (1) Morphology: a) A pilot study on determining the effects of treating retinal laser injury with near infrared light did not show promise for saving damaged photoreceptors. b) Photochemical lesions are more difficult to produce, and are almost undetectable after only one week. (2) Electrophysiology: A technique to record pattern electroretinographic responses from the snake eye has been developed, and will be used for visual function testing; and (3) Biochemistry: the study of the cellular make up of the rat snake retina is ongoing, and is providing further evidence that this retina is an all cone retina.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2003
- Accession Number
- ADA419373
Entities
People
- Andy Tsin
- Heike Rentmeister-bryant
- Randolph Glickman
- Rowe Elliott
Organizations
- Naval Health Research Center