Genetic Susceptibility to Prostate Cancer in the Netherlands

Abstract

Studies of the genetics of populations that were historically endogamous for reasons of geography, religion, or language have contributed substantially to our understanding about hereditary predisposition to cancer. One such population is found in the Netherlands where multiple, prevalent, population-specific founder mutations have been identified. Genetic susceptibility to prostate cancer is being investigated in the Netherlands Cohorts Study (NLCS) on Diet and Cancer, which has identified over 800 cases of prostate cancer among 58,279 male participants. From this study, we have identified 300 cases and 300 controls from among men of comparable age to identify markers near prostate cancer susceptibility genes that are present at higher frequency in the group of men with prostate cancer. We have optimized the methods for analysis of these markers. During the next year, we will apply these methods to analyzing the samples that have been collected.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2003
Accession Number
ADA419376

Entities

People

  • Harry Ostrer

Organizations

  • New York University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Chromosomes
  • Genetics
  • Genotypes
  • Geographic Regions
  • Magnesium Compounds
  • Medical Personnel
  • Microsatellites
  • Neoplasms
  • Netherlands
  • New York
  • Prostate
  • Prostate Cancer
  • Regression Analysis
  • Standards
  • Statistical Analysis
  • Tissues

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology