Prostate Stem Cell Antigen (PSCA): A Promising Prognostic Marker and Therapeutic Target in Prostate Cancer
Abstract
PSCA is a cell surface protein identified in our laboratory, which is expressed in a majority of prostate cancers. The major goals of this grant were to determine the expression of PSCA in localized and metastatic prostate cancer, to determine if expression correlated with clinicopathologic features of prostate cancer, and whether PSCA expression could be detected in bone marrow. Over the past year, we have completed the major portions of Aim 1, determining PSCA expression in a prostate cancer tissue microarray and in a large number of prostate cancer metastases. This has resulted in a publication in press at the Journal of Urology. The major finding is that PSCA expression increases with tumor stage and grade and correlates with a higher risk of cancer recurrence. PSCA is also expressed in 85% of bone metastases, making it a reasonable target for antibody therapy. A prospective study of PSCA in biopsies is underway.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2003
- Accession Number
- ADA419393
Entities
People
- Robert E. Reiter
Organizations
- University of California, Los Angeles