Mechanisms of Virus-Induced Neural Cell Death
Abstract
We are using experimental infection with reoviruses to study how viruses induce cell death. (apoptosis), and the significance of apoptosis in the pathogenesis of viral infection. We have developed one of the best-characterized experimental models for investigating and manipulating viral cell death pathways. We have shown that apoptosis is a major mechanism of reovirus-induced cell death in murine models of key human viral infections including myocarditis and encephalitis. We have shown that apoptosis is a major mechanism of reovirus-induced cell death in murine models of key human viral infections including myocarditis and encephalitis. We have shown-that inhibiting apoptosis can reduce the degree of virus-induced histological injury in target organs and prolong the survival of infected animals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA419455
Entities
People
- Kenneth L. Tyler
Organizations
- University of Colorado Health