A Multidisciplinary Approach to Generating Effective Therapeutics for Emerging Hantaviruses

Abstract

The major goals of this project are to purify hantavirus proteins (Jonsson) for X-ray structure determination (Arnold). By defining the three-dimensional structures of the N and RDRP proteins of hantaviruses, our studies will afford a means to model drugs that specifically interfere with important stages of viral replication. -Particularly, disrupting one or more functions of the RDRP is expected to result in effective disease treatment with little toxicity to host cells. In addition, our research will yield a high through-put in vitro assay for identification of new antiviral drugs. Together, these studies should lead toward effective therapeutic measures for controlling and treating hantaviral infections.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2003
Accession Number
ADA419495

Entities

People

  • Colleen B. Jonsson
  • Edward Arnold

Organizations

  • New Mexico State University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Antiviral Agents
  • Bunyaviridae Infections
  • Chemistry
  • Diseases And Disorders
  • Enzyme Inhibitors
  • Identification
  • Infection
  • Infectious Diseases
  • Materials
  • New Mexico
  • Proteins
  • Rna Viruses
  • Therapy
  • Three Dimensional
  • Viruses
  • Wound Infections

Readers

  • Molecular Genetics
  • Systems Analysis and Design
  • Virology (or Medical Virology).