Environmental Medicine Genome Bank (EMGB): Annual Report and Project Summary
Abstract
The Environmental Medicine Genome Bank (EMGB) project is an ongoing effort to identify and characterize genes relevant to environmental illnesses and to human physical performance. To accomplish this, the EMGB banks DNA samples from human volunteers who have participated in environmental and human performance studies or material obtained under approved Brigham and Women's Hospital protocols that would otherwise have been discarded. The EMGB maintains a registry of this phenotypic information. The EMGB can be used to identity polymorphisms in genes that are potentially of interest to environmental medicine and to obtain an estimate of the frequency of these polymorphisms in young, healthy U.S. adults because of the ethnically diverse and geographically dispersed backgrounds of the donors. Additionally, this resource also serves as a valuable source of control material for genetic studies of human diseases, such as asthma. The project is performed as part of a cooperative research and development agreement (CRDA) with the Division of Pulmonary and Critical Care Medicine at Brigham and Women's Hospital. B-lympohcytes immortalized using the Epstein Barr Virus (EBV) are incorporated into the EMGB in attempts to maintain stocks of genetic material that are characterized by phenotype. These samples include cells and DNA from asthmatics, as from characterized non-asthmatics.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA419507
Entities
People
- Craig M. Lilly
- Larry A. Sonna
- Nicholas J. Messinese
Organizations
- United States Army Research Institute of Environmental Medicine