The Role of Human Spectrin SH3 Domain Binding Protein 1 (HSSH3BP1) in Prostatic Adenocarcinoma

Abstract

Prostate cancer is one of the leading causes of cancer-related deaths in the United States and a leading diagnosed cancer in American men. Newly diagnosed cases of prostate cancer approach rapidly the number of 200,000 cases per year. Genetic alterations of tumor suppressor genes are one of the most common causes of prostate cancer tumorigenesis. Our group identified Hssh3bp1 as a candidate prostate tumor suppressor gene. In this research we are testing the tumor suppressor function of the candidate gene in prostatic adenocarcinoma using in vitro and in vivo assays.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2003
Accession Number
ADA419543

Entities

People

  • Edward C. Jones
  • Jiliu Xu
  • Jill Macoska
  • Leszek Kotula
  • Magdalena Martinka
  • Piotr Kozlowski

Organizations

  • Research Foundation For Mental Hygiene

Tags

DTIC Thesaurus Topics

  • Adenocarcinoma
  • Amino Acids
  • Army
  • Biomedical Research
  • Cancer
  • Carrier Proteins
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Cultured Cells
  • Health Services
  • Kinases
  • Phosphorylation
  • Prostate Cancer
  • Proteins
  • Tissues
  • Tyrosine

Fields of Study

  • Medicine

Readers

  • Molecular and Cellular Biochemistry
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology