Electron Transfer of Redox Enzymes to Inorganic Electrodes
Abstract
This project was to develop a protein and peptide-based nanowire and nanoswitch with defined length and properties for a broad spectrum of application in nanobiotechnology. These nanowires were used to develop novel enzyme/conductive matrix in which the activity of redox enzymes could be controlled by direct electron transfer to inorganic electrodes. We investigated synthetic peptide structures as linking agents between target enzymes and conductive electrodes. Directly couple nanocrystals to amino acids, peptide and proteins. This was carried through several methods. One was to couple the nanocrystals to peptides and proteins directly. But the yield was very low and become prohibitively expensive. The alternative was to first couple the nanocrystals to amino acids and through chemical synthesis to make peptides and proteins. We have successfully achieved it.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2003
- Accession Number
- ADA419613
Entities
People
- Shuguang Zhang
Organizations
- Massachusetts Institute of Technology