Targeting the AP-1 Transcription Factor for the Treatment of Breast Cancer

Abstract

The AP-1 transcription factor is a central component of many signal transduction pathways. We have shown that blocking AP-1 by over-expressing a dominant negative form of cJun (cjun-DN, Tam67) inhibits breast cancer cell growth. We hypothesize that inhibition of AP-1 blocks the cell cycle, suppression of AP-1 in vivo inhibits the development of breast tumors, the cjun-DN protein binds and inactivates important growth regulatory proteins present in breast cancer cells, these proteins include Jun and Fos family members as well as coactivators that bind cJun. In the present study, we demonstrated that TAM67 inhibits breast cancer growth both in vitro and in vivo. We determined the mechanism by which AP-1 blockade inhibits breast cancer growth.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2003
Accession Number
ADA419669

Entities

People

  • Chunhua Lu

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Breast Cancer
  • Carrier Proteins
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Culture Techniques
  • Department Of Defense
  • Growth Factors
  • Inhibition
  • Inhibitors
  • Molecular Dynamics
  • Neoplasms
  • Peptide Growth Factors
  • Programmed Cell Death
  • Transcription Factors
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Rocket Propulsion.