A Study of Transrectal Tumor Oxygen Measurements in Patients With Clinically Localized Prostate Cancer
Abstract
The primary aim of this clinical study is to determine the relationship between pre- treatment prostate cancer oxygen levels and long-term disease control following treatment with radiotherapy, and the independent prognostic effect of oxygen measurements relative to established prognostic factors. In addition, the study will determine the relationship between pre-treatment tumor oxygen levels and mutations of the p53 tumor suppressor gene, and the impact of this interaction on patient outcome. The accrual rate increased in year 2 and is now close to the value anticipated when the study was designed. Nevertheless, because of slower than expected accrual I year 1 and disruption in clinical and research activity in year 2 by Severe Acute Respiratory Syndrome (SARS), it is anticipated that accrual will need to be extended into year 4 to meet the target of the 195 patients. The oxygen measurement technique was revised based on the results of our pilot study to assure that the highest quality data are being collected. The microregional distribution of oxygen in prostate cancer biopsies will be studied using intrinsic markers of oxygenation. The molecular studies of p53 are proceeding as outlined in the proposal. It is anticipated that all aspects of the proposed work will be completed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2003
- Accession Number
- ADA419673
Entities
People
- Michael F. Milosevic
Organizations
- University Health Network