Bioactive Lipids: Role in Prostate Cancer Angiogenesis

Abstract

Angiogenesis is an integral part of human prostate cancer progression. In the Phase I of this grant, we have identified arachidonate 12-lipoxygenase as a promoter of angiogenesis in human prostate carcinoma by stimulating VECF expression and via the pro-angiogenic activity of 12(S)-HETE. The first objective of phase II of this grant is to delineate the regulation of VEGF gene expression by 12-LOX in PCa cells, specifically the involvement of Spl and possibly AP2. The second objective of this proposal is to describe the signal transduction pathway by which 12-LOX stimulates VEGF expression. These two objectives are based upon our observations in the Phase I of this grant that 12-LOX, when overexpressed in human PCa cells, stimulates tumor angiogenesis and growth. The third objective to evaluate the therapeutic potential of 12-LOX inhibitors for PCa treatment.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2003
Accession Number
ADA419706

Entities

People

  • Kenneth V. Honn

Organizations

  • Wayne State University

Tags

DTIC Thesaurus Topics

  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Enzyme Inhibitors
  • Health Services
  • Peptide Growth Factors
  • Proteins

Fields of Study

  • Biology
  • Medicine
  • Physics

Readers

  • Molecular Biology and Genetics
  • Prostate Cancer Biology.