Is Breast Tissue from Women Who Carry Germ-Line BRCA1 or BRCA2 Mutations "Normal"? - An Immuno-Histopathological Study

Abstract

After review of 140 files, a total of 90 prevalent cases of breast cancer were recruited from both clinical genetic services at the Montreal Hospital sites. A total of 36 cases were examined by three separate blinded pathologists for certain morphological and histological features to be compared among carriers and non-carriers of the BRCAl/2 genes. The pre-cancerous features that we focused on included apocrine hyperplasia, sclerosing adenosis, columnar alteration with prominent apical snouts and secretions(CAPSS) and usual ductal hyperplasia. We are now in the process of having the remaining 24 cases examined and reviewing the raw data to establish some results and conclusions. We hope to complete the examination of the remaining cases and the analysis of the raw data very shortly. Immunohistochemical analysis will follow.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2003
Accession Number
ADA419802

Entities

People

  • Gilles Tremblay
  • Lesley Alpert
  • Louise Quenneville
  • William David Foulkes

Organizations

  • Jewish General Hospital

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Classification
  • Data Analysis
  • Data Sets
  • Electronic Mail
  • Health Services
  • Hospitals
  • Hyperplasia
  • Medical Personnel
  • Mutations
  • Neoplasms
  • Pathology
  • Physicians
  • Secretion
  • Statistical Analysis

Fields of Study

  • Medicine

Readers

  • Molecular and genetic basis of cancer.
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology