Genetic Variation in the HSD3B2 Gene and Prostate Cancer
Abstract
Prostate cancer is the most common cancer in American men. It is also characterized by a substantial racial/ethnic variation in risk: highest in African-American men, lowest in Asian men and intermediate in Caucasian and Latino men. We propose to investigate genetic variants of genes involved in the regulation of prostatic growth and particularly in androgen metabolism, particularly the HSD3B2 gene which encodes the type II beta-hydoxysternid dehydrogenase. Our current progress is highlighted by the following three findings. First, our data indicate that the locus under investigation is highly polymorphic in constitutional DNA. Furthermore, our population-based investigations are proceeding according to plan with MAPA technology. Finally, our initial biochemical results suggest that this aim will also be completed soon.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA419804
Entities
People
- Juergen Reichardt
Organizations
- University of Southern California