Examination of the Contribution of VEGF to the Metastatic Dissemination of c-Myc Overexpressing Breast Cancer Cells

Abstract

Metastasis to the lung is a common occurrence accounting for approximately 60-70% of metastasis. We have developed a transgenic model of lung metastasis using a MMTV-c-myc/MMTV-VEGF bitransgenic mouse system. We are using this system to evaluate the mechanism by which VEGF is able to dramatically increase metastasis to the lung. Solid progress has been made during a no-cost extension year granted to allow us to re-group and overcome technical challenges that have slowed the anticipated accrual of tumor material for the study. Three publications are in the final stages of publication which have been directly supported by this award.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2003
Accession Number
ADA420071

Entities

People

  • Michael D. Johnson

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Culture Techniques
  • Diseases And Disorders
  • Electronic Mail
  • Growth Factors
  • Information Operations
  • Mammary Glands
  • Materials
  • Medical Personnel
  • Metastasis
  • Neoplasms

Readers

  • Oncology (Cancer Research).
  • Technical Research and Report Writing.