An Epithelial-Derived Integral Membrane Kunitz-Type Serine Protease Inhibitor in Breast Cancer
Abstract
In the current research plan, we proposed to study the anti-tumor and anti-protease activity of a membrane-bound Kunitz-type serine protease inhibitor (KSPI; also known as HAI-1). In order to investigate how HAI-1 regulates matriptase function, we have constructed mutants of the HAI-1 proteins, including point mutations at the active center of both Kunitz domains and the calcium cage of the LDL receptor class A domain, and the deletion of entire LDL receptor class A domain.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2003
- Accession Number
- ADA420072
Entities
People
- Chen-yong Lin
Organizations
- Georgetown University