Influences of Nutrition and Physical Forces on Bone Structure/Function Properties
Abstract
The purpose of this research program is to contribute towards two major objectives in support of advancing our ability to prevent or treat bone failure or fragility: I. Developing and characterizing methods of evaluating bone properties in animal models that goes beyond measures of bone density and global mechanical properties. 2. Evaluating the influence of physical forces and nutritional status on bone biomechanical integrity. Specifically, it was the purpose of this study to apply a hierarchical approach to quantifying the properties of murine bone to the level of the extracellular matrix. Furthermore, the study was designed to test hypotheses concerning the interplay between vitamin D and calcium nutritional support and physical forces. Progress during the second year of study has followed the proposed statement of work. All of the microtesting systems have been fabricated and are being utilized to prepare specimens for study. Most importantly, 394 animals have been entered into the study and the morphology, geometry and mechanical properties of the femurs and vertebrae have been documented for many of the animals. The data demonstrated significant effects of strain and calcium nutrition, with no effect of exercise to date.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2003
- Accession Number
- ADA420075
Entities
People
- Steven A. Goldstein
Organizations
- University of Michigan