NSAIDS and the Osteogenic Response to Mechanical Stress in Prememopausal Women
Abstract
This is a study of the effects of ibuprofen, a non-steroidal anti-inflammatory drug (NSAlD), on the osteogenic response to 9 months of exercise training in healthy, premenopausal women, aged 21 to 40 years (N=1 02). The hypotheses are: H1a: taking short-acting NDSAlDS before exercise will diminish increases in bone mineral density (BMD) in response to exercise training H1a: taking short-acting NSAlDS after exercise will not diminish the increases in BMD in response to exercise training Participants take either ibuprofen (4OOmg) or placebo capsules before and after each exercise session. Women are randomized to three treatment arms: 1) NSAlD before exercise, placebo after exercise (NSAIDIplacebo; n=34); 2) placebo before exercise, NSAlD after exercise (placebo/NSAlD; n=34); and 3) placebo before exercise, placebo after exercise (placebo/placebo; n=34). Fifty-three subjects have completed baseline testing and are currently enrolled in the study. Fifteen subjects are presently scheduled for or are undergoing baseline testing. These studies could lead to the development of new strategies to reduce the incidence of, and treatment for, stress fractures that occur in response to vigorous physical activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2003
- Accession Number
- ADA420084
Entities
People
- Wendy M. Kohrt
Organizations
- University of Colorado Health