DNA Damage, Fruits and Vegetables and Breast Cancer Prevention

Abstract

The purpose of this project was to evaluate the effect(s) of increasing fruit and vegetable intake on oxidative DNA damage and lipid peroxidation in a population of women at elevated risk for breast cancer. The rationale that underlies the work conducted was based on evidence that the occurrence of DNA mutations are essential steps in carcinogenesis and that these mutagenic events can result from oxidative stress, even in the absence of exogenous carcinogens. The effects of consuming a recipe-defined diet designed to provide on average three (control) or ten (intervention) servings of fruits and vegetables per day for a total of 8 weeks on measures of oxidative damage to DNA and lipids was determined. The accrual goal of enrolling 200 subjects in this project was exceeded. A total of 213 individuals completed the dietary intervention. Sample analysis and data evaluation are reported.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2003
Accession Number
ADA420088

Entities

People

  • Henry J. Thompson

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Body Weight
  • Breast Cancer
  • Cancer
  • Chemical Synthesis
  • Chemistry
  • Convenience Foods
  • Data Science
  • Food
  • Information Science
  • Meals
  • Medical Personnel
  • Neoplasms
  • Oxidative Stress
  • Statistics
  • Vegetables
  • Vitamin C
  • Vitamin E

Readers

  • Gender and Food Studies
  • Molecular and genetic basis of cancer.
  • Prostate Cancer Biology.