The Effects of Total Sleep Deprivation and Recovery Sleep on Cognitive Performance and Brain Function
Abstract
An ever-increasing number of military personnel and civilians alike must work daily without adequate sleep. Although considerable data show sleep deprivation alters many aspects of behavior, little is known about changes in the brain substrate underlying the behavioral effects.. Even less is known about the cerebral effects of recovery sleep. The objective of this study is to investigate the effects of 2 full nights of sleep loss and 2 full nights of recovery sleep on cognitive performance and brain function. We will study 40 individuals for 6 nights and 6 days. Over the course of this period, subjects will receive 4 polysomnograms and 10 functional magnetic resonance imaging (FMRI) sessions. During the FMRI sessions, functional brain imaging data will be collected while subjects perform each of 3 cognitive tasks: sustained attention, arithmetic working memory, and verbal learning. In addition to these 40 individuals in the sleep deprivation protocol, we will recruit 10 separate individuals who will participate only in the FMRI portion of the protocol, not the sleep or sleep deprivation portions. These data will allow us to determine the effects on FMRI measures of brain activation due to repeated measurements, independent of any sleep or sleep deprivation related effects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2003
- Accession Number
- ADA420120
Entities
People
- Gregory Brown
- J. C. Gillin
- Sean P. Drummond