FCCC Institutional Breast Cancer Training Program (FCCC-IBCTP)
Abstract
The present report covers the fork performed by four different trainees working in: i-Predispostion to genomic instability in breast cancer: analysis of molecular mechanisms. The goal of this research is to better understand intrinsic genetic factor leading to genome instability, with the intent of improving diagnosis and treatment for breast cancer. ii-Proline 47 is important in mediating p53-dependent apoptosis. We are studying a rare polymorphism of p53 that changes the praline. Residue at amino acid 47 to Serine. iii- Development of a Mouse Model for the Targeted Disruption of the Appl Gene in Mammary Gland. To date, APPL is the only adaptor reported to interact with AKT kinases. Since AKT2 appears to play a more prominent role in human neoplasia than other members of he AKT family, the characterization of APPL may provide important insights regarding oncogenic mechanisms involving AKT2. iv-Cloning of a new gene/s in chromosome 17p13.2-13.1 that control apoptosis. The aims are to isolate in the precise location in chromosome 17p13.2- p13.1 the gene(s) responsible for the control of Fas-receptor ligand complex function and to test the cloned gene/s functionality in cell transformation by cDNA transfection studies in vitro.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA420153
Entities
People
- Jose Russo
Organizations
- Fox Chase Cancer Center