CBP and Extracellular Matrix-Induced Apoptosis in p53(-) HMECs: A Model of Early Mammary Carcinogenesis

Abstract

Interactions between normal mammary epithelial cells (HMECs) and extracellular matrix (ECM) are important for mammary gland homeostasis and loss of ECM-sensitivity is an early event in mammary carcinogenesis. The purpose of this grant is to investigate how the CREBP-binding protein (CBP) might target the elimination of damaged HMECs. We have observed that 1) suppression of CBP results in apoptosis-resistance through impaired laminin expression and 2) CBP promotes induction of interferon-regulated genes during apoptosis. These findings will provide novel targets for chemoprevention and are being used to develop markers for response to current prevention strategies.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2003
Accession Number
ADA420160

Entities

People

  • Victoria L. Seaweldt

Organizations

  • Duke University Hospital

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Breast Cancer
  • Cancer
  • Carrier Proteins
  • Cell Membrane Structures
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Techniques
  • Epithelial Cells
  • Intercellular Junctions
  • Neoplasms
  • Oncology
  • Papillomavirus Infections
  • Polymeric Films
  • Programmed Cell Death
  • Proteins

Fields of Study

  • Biology
  • Medicine

Readers

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  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology