Enhancement of Prostate Cancer Radiotheraphy by Immunogenetherapy

Abstract

The long-term goal of the proposed study is to develop a genetic immunotherapy strategy that can compliment and enhance current prostate cancer radiotherapy. The specific strategy that will be adopted in this proposal is to test the capacity of an adenovirus encoding immunostimulatory genes IL-12 and B7 to enhance the therapeutic effects of ionizing radiation in an experimental murine prostate tumor model TrampC. A substantial progress has been made towards this goal. We have now conducted experiments where we combined radiotherapy and genetic immunotherapy in the TrampCl model. The results indicate synergistic effects in controlling subcutaneous tumor growth. We have also developed a murine prostate cancer model where tumor growth can be imaged non-invasively through a innovative bioluminescence imaging system. We anticipate this model will greatly facilitat our future studies on prostate cancer metastases.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2003
Accession Number
ADA420196

Entities

People

  • Li Chuan-yuan

Organizations

  • Duke University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Classification
  • Electronic Mail
  • Maryland
  • Monitoring
  • Neoplasms
  • North Carolina
  • Prostate
  • Prostate Cancer
  • Radiotherapy
  • Security
  • Universities

Fields of Study

  • Biology
  • Physics

Readers

  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech