Genetic Polymorphisms, Estrogens, and Breast Density

Abstract

During this year we have completed the genotyping and urine analysis for estrogen metabolites and proceeded with the statistical analysis. We have completed two investigations that addressed the following specific aims: 1. To examine the association between polymorphism in genes coding for metabolism and biosynthesis of estrogens (COMT CYP1A1, CYP1A2, CYP1B1, and CYP17) and mammographic densities in healthy women with different ethnic backgrounds. 2. To analyze the relation of mammographic density with the urinary excretion of hormones and the urinary ratio of 2-OHE(1)/16 alpha OHE1.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2003
Accession Number
ADA420215

Entities

People

  • Gertraud Maskarinec

Organizations

  • University of HawaiĘ»i System

Tags

DTIC Thesaurus Topics

  • Anabolism
  • Breast Cancer
  • Cancer
  • Data Science
  • Databases
  • Drug Therapy
  • Estrogens
  • Ethnic Groups
  • Genes
  • Genetic Variation
  • Hormones
  • Information Science
  • Liquid Chromatography
  • Metabolism
  • Neoplasms
  • Sex Hormones
  • Statistical Analysis

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and genetic basis of cancer.
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology