The Role of Ckh2 in Breast Cancer
Abstract
Breast cancer is a very heterogeneous disease. Many pathological alterations contribute to breast cancer development. Some initiate the cancer formation or accelerate its progression. Our bodies counter DNA damaging stressed form the environment, such as g-irradiation, UV, carcinogens or even from metabolic processes. If DNA damage occurs without being repaired n the genes controlling cell growth or morality, cells will acquire altered growth properties and become transformed and cancer will eventually develop. Fortunately, our bodies have natural defense mechanisms called checkpoints to keep the damaged cells in check so that the damaged genes can be repaired. In this proposal, we plan to study Chk2, one of the central components of the machinery, for its role in managing our defensive system to repair damaged DNA and to suppress cellular transformation. In our studies, we will first generate cells or animals which have no Chk2 expression for use as a model. By studying the responses to DNA damaging agents and the transformation potential, we can determine the significance of Chk2 functions in managing checkpoints and in suppressing transformation. Next, we plan to systematically identify Chk2 substrates and its associated proteins so that we can discover the entire network connecting to Chk2.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2003
- Accession Number
- ADA420342
Entities
People
- Stephen Elledge
Organizations
- Baylor College of Medicine