Therapeutic and Chemopreventive Actions of a Novel Polyamine Analog Against Breast Cancer
Abstract
The intracellular polyamines, spermidine, spermine, and putrescine, play an important role in the proliferation and death of normal and malignant cells. As a consequence, our work has focused on development of inhibitors of this metabolic pathway. A phase II trial of diethylnorspermine (DENSpm) for women with advanced breast cancer was completed. No major toxicity was observed but clinical activity was not sufficient to warrant further testing of DENSpm at the dose and schedule used. Analysis of DENSpm- and control-treated breast cancer tumors derived form discarded mastectomy tissue showed that DENSpm can modulate expression of the SSAT enzyme on some specimens. This could potentially serve as a biomarker of effect the efficacy of several new polyamine ananogs as treatment for established breast cancer in a nude mouse model zenograft has been demonstrated. Future studies will focus on these agents.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA420346
Entities
People
- Nancy E. Davidson
Organizations
- Johns Hopkins University